Emojis present accessibility challenges for blind and low-vision (BLV) individuals, particularly when navigating through screen reader interfaces. Interpretations of emojis have been extensively researched, highlighting the influence of cultural differences on individual comprehension, the need to proactively avert potential misunderstandings, to explore the denotations and connotations of emojis, and the use of emojis in online communication. This paper explores the challenges of emoji interaction for blind and low-vision (BLV) users within the field of Human-Computer Interaction (HCI), focusing on the absence of visual cues and the resulting ambiguity in emoji affordance when using screen readers. This study examines communication barriers in digital environments, highlighting the need for user-centered design within Information and Communication Technologies (ICTs). It proposes strategies to improve emoji accessibility and non-visual communication experiences for BLV users, drawing on insights from semi-structured interviews, co-design sessions, and user testing.