In this paper, I utilize scientific theories surrounding the neurological condition synesthesia to identify how multisensory installation art can challenge our understanding of the singularity of the senses. This exploration will form the basis of my theory of “synthetic synesthesia,” a term derived from my observation of synesthetic components in installation artworks that possess elements of multisensoriality, embodiment and immersion. This theory is applied to my analysis of select pieces by Marla Hlady and Peter De Cupere whose works involve sensory combinations, such as vision/hearing/touch (Hlady), and vision/olfactory (De Cupere). The works of both of my case studies reconsider how the participant interacts with an artwork by creating installations which augment the traditional visual art experience.