At the end of a healthcare visit, information may be supplied all at once, which can result in challenges with retaining and understanding information that may lead to a mismanagement of prescribed treatment (Becker et al. 2021). Further, those who identify as neurodivergent – a term that may be defined to describe “individuals whose selective neurocognitive functions/ neurodevelopmental differences fall outside prevalent societal norms” – may have specific information needs that are not generally addressed by standard healthcare information-delivery practices (Shah et al., 2022, p. 579). There remains a need to consider how to better support inclusive communication practices between neurodivergent patients, caregivers and healthcare providers at the end of healthcare visits. Drawing from Shannon’s Theory of Information, this research paper considers the concept of noise, which refers to information that disrupts or distorts a transmitted message (Shannon & Weaver, 1949). In this healthcare context, barriers to understanding healthcare instructions are conceptualized as noise. This study leverages semi-structured interviews and an iterative co-design process to identify sources of noise and opportunities to respond to these barriers to inclusive healthcare communication between neurodivergent patients, caregivers and healthcare providers. We propose a model for organizing noise into four categories: (1) less controllable external noise, (2) more controllable internal noise, (3) less controllable internal noise, and (4) more controllable external noise. Our discussion considers what types of action are required to mitigate different forms of noise. Systemic action – that is, action required to address less controllable external noise – is analyzed and compared to a design thinking process. We identify an opportunity to offload the burden of enacting systemic action through collaborative efforts between healthcare providers and designers. Overall, this research makes a unique academic contribution by considering how information theory can extend our understanding and response to healthcare communication barriers between neurodivergent patients, caregivers and healthcare providers.