Healthcare organizations are challenged to deliver world class care in an increasingly complex environment. That environment is widely viewed as a complex adaptive system and requires the recognition that checklists alone are not the only answer to support clinicians, such as nurses, in their efforts to deliver safe care. The focus of the healthcare system is on population health and as such the elements that define quality include that it be safe, effective, patient centered, efficient, timely and equitable. The dimensions of safe care and effectiveness is primarily clinical and clinicians closest to the patient are in the best position to address this. This paper asks the question “How might clinicians be supported as they work to deliver safe care.” and explores the landscape of patient safety interventions through the nurses’ perspective. The aspiration of this project is to introduce a synthesis of the problem space to help those with a vested interest in supporting nursing achieve their goal of providing safe and ethical care to the public.