This study explored the current-state urban office environment in the Greater Toronto Area, examining whether a deficit of nature influences the stress employees experience at work. Mixed research methods were used to conduct the study, including a literature review, expert interviews, surveying methods, and in-context interviews with people working in Toronto offices. The study demonstrates that people who live in cities have a strained relationship with nature; that the stress experienced from city life and office environments is made worse by this disconnection from nature; and that if offices were designed differently—to better integrate nature into our daily lives—people would likely feel mentally and physically healthier. The findings potentially have implications for three levels of stakeholders—employers, designers, and policymakers. Recommendations include tactics to better integrate nature in everyday activities in city environments to mitigate the impact of nature deficit.